The McKee Laboratory focuses on the application of engineering principles and bioinformatics tools to the interrogation of biological processes.
We have a number of ongoing projects in computational pathology, in which we utilize computer vision-based tools for image segmentation and object classification in order to turn an image with pixels into a biological network of cells for further interrogation.
We also generate multi-modality 3D and 4D image datasets, and develop new techniques utilizing a radiomics-based approach for the interrogation of images and the fusion of volumetric image data with high resolution pathology data.
Finally, we are working on the fundamental infrastructure required for handling these data types, with the goal of developing and improving upon open-source tools available for the generation and utilization of segmented image data, for use by large collaborative projects like the Human Cell Atlas.